Description

α-2'-Deoxyoctathymidylate Phosphorothioate is a synthetic oligonucleotide analog where a non-bridging oxygen atom in the phosphate backbone is replaced with sulfur, creating a phosphorothioate (PS) linkage. This modification confers enhanced nuclease resistance and improved pharmacokinetic properties, making it a critical building block for advanced therapeutic and diagnostic applications. It is primarily utilized by research institutions and biotechnology companies engaged in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Core component for constructing therapeutic oligonucleotides designed to modulate gene expression by binding to specific RNA sequences.
• siRNA and miRNA Agonist/Antagonist Production: Used in the solid-phase synthesis of chemically modified small interfering RNA (siRNA) or microRNA mimics/inhibitors to enhance stability and efficacy.
• Diagnostic Probe Development: Serves as a stable, labeled probe in fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Apitamer Research: Building block for creating nuclease-resistant aptamers used in targeted drug delivery and biosensing.
• Pharmaceutical R&D: Essential raw material in preclinical and clinical development of novel genetic medicines.
• Biochemical Tool: Used in fundamental research to study nucleic acid-protein interactions, enzyme mechanisms, and cellular uptake pathways.

Basic Information

Product Name	α-2'-Deoxyoctathymidylate Phosphorothioate
CAS No.	138704-97-9
Molecular Formula	C80H98N16O49P7S7
Molecular Weight	2479.7 g/mol (theoretical)
Synonyms	d(Tps)7; Phosphorothioate Octathymidylate; PS-Oligo(dT)8; Octathymidylic Acid Phosphorothioate; 2'-Deoxy-8-thymidine Phosphorothioate Homopolymer; Antisense Oligonucleotide d(T)8 PS; Oligothymidylate Phosphorothioate
EINECS	Contact for details

Quality Control

Every batch of α-2'-Deoxyoctathymidylate Phosphorothioate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements for pharmaceutical-grade oligonucleotide intermediates. Certificates of Analysis (COA) detailing purity by HPLC, identity by mass spectrometry, and other critical parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 85%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.