Description

Afovirsen Sodium is a synthetic oligonucleotide sodium salt with significant antiviral research applications. This compound is a critical intermediate and active ingredient in the development of novel therapeutic agents targeting viral infections. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on antiviral drug discovery and mechanism studies.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or active pharmaceutical ingredient (API) in the synthesis of antiviral medications.
• Antiviral Research: Used in biochemical and cellular assays to study mechanisms of viral inhibition and to screen for new therapeutic candidates.
• Biotechnology Development: Employed in the development of oligonucleotide-based therapies, including antisense and aptamer technologies.
• Academic & Preclinical Studies: Facilitates fundamental research into virology and the pharmacokinetics/pharmacodynamics of nucleotide analogs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	Afovirsen Sodium
CAS No.	138330-98-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Afovirsen Sodium Salt; ISIS 2105; ISIS-2105; 5'-d(TTTTTTTTTTTTTTTTTTTT)-3' Sodium Salt (Sequence specific); ISIS2105; Afovirsen (sodium); Antisense Oligonucleotide ISIS 2105; GEM® 91 Sodium Salt
EINECS	Contact for details

Quality Control

Our Afovirsen Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and stringent controls for residual solvents and endotoxins. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption. For long-term stability, consider storage at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0% (Total Oligonucleotide)
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.