Description

Mant-Gtpγs (Aqueous Solution) is a high-purity, non-hydrolyzable GTP analog used extensively in biochemical research to study G-protein coupled receptor (GPCR) signaling pathways. Its core value lies in its ability to provide stable, long-lasting activation of G-proteins, making it an essential tool for investigating signal transduction mechanisms. This product is critically needed by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for applications in drug discovery, molecular pharmacology, and cellular biochemistry.

Application

• GPCR Signal Transduction Research: Used as a potent and stable activator of Gα subunits to study receptor-effector coupling.
• Drug Discovery & Screening: Employed in high-throughput assays to identify and characterize novel agonists or antagonists for GPCR targets.
• Biochemical Assay Development: Serves as a critical reagent in developing and validating assays for G-protein activity, such as GTPase or GTP-binding assays.
• Cellular Pathway Analysis: Facilitates the study of downstream cellular responses, including second messenger production (e.g., cAMP, calcium) and kinase activation.
• Membrane Protein Studies: Used in reconstitution experiments with purified receptors and G-proteins to elucidate mechanistic details of signal initiation.
• Academic & Basic Research: A fundamental tool for investigating the structure, function, and regulation of heterotrimeric G-proteins.

Basic Information

Product Name	Mant-Gtpγs (Aqueous Solution)
CAS No.	136749-24-1
Molecular Formula	C₁₇H₂₂N₆O₁₇P₃S
Molecular Weight	722.37 g/mol
Synonyms	2'/3'-O-(N-Methylanthraniloyl)guanosine-5'-O-[γ-thio]triphosphate; Mant-GTPγS; MANT-GTPγS; N-Methylanthraniloyl-GTPγS; Guanosine 5'-[γ-thio]triphosphate, 2'(3')-O-(N-methylanthraniloyl)-; Fluorescent GTPγS analog; Non-hydrolyzable GTP analog; G-protein activator
EINECS	Contact for details

Quality Control

Our Mant-Gtpγs (Aqueous Solution) is manufactured under stringent conditions to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot undergoes rigorous quality testing, including purity analysis by HPLC and functional validation in standard G-protein activation assays. Certificates of Analysis (COA) detailing purity, concentration, and performance data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the aqueous solution at -20°C or below. Avoid repeated freeze-thaw cycles. Under these recommended conditions, the product is stable for extended periods.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95%
Concentration	Typically 1-10 mM in aqueous buffer (customizable)
pH	6.5 - 7.5
Functional Activity	Validated in standard G-protein activation assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.