Description

5-Methoxy-1,2,3,4-Tetrahydro-n-(Phenylmethyl)- 2-Naphthalenamine (Rotigotine) is a synthetic aminotetralin derivative that serves as a critical active pharmaceutical ingredient (API). This compound matters as a potent, non-ergoline dopamine agonist used in the treatment of Parkinson's disease and restless legs syndrome. Pharmaceutical manufacturers and advanced research organizations require this high-purity intermediate for the synthesis of final drug formulations and novel therapeutic development.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use in the manufacture of Rotigotine, a dopamine agonist medication.
• Neurological Disorder Therapeutics: Key intermediate for drugs targeting Parkinson's disease and restless legs syndrome (RLS).
• Pharmaceutical Research & Development (R&D): Used in preclinical and clinical studies for central nervous system (CNS) disorders.
• Transdermal Drug Delivery Systems: A critical component in the development of patch-based delivery formulations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing.
• Process Chemistry & Scale-Up: Employed in process optimization and commercial-scale pharmaceutical production.

Basic Information

Product Name	5-Methoxy-1,2,3,4-Tetrahydro-n-(Phenylmethyl)- 2-Naphthalenamine (Rotigotine)
CAS No.	136247-07-9
Molecular Formula	C19H25NO
Molecular Weight	283.41 g/mol
Synonyms	Rotigotine; Rotigotine Base; (-)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthol; N-0923; (6S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydro-1-naphthalenol; 2-Naphthalenamine, 5-methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)-; N-Benzyl-5-methoxy-1,2,3,4-tetrahydro-2-naphthylamine
EINECS	Contact for details

Quality Control

Our 5-Methoxy-1,2,3,4-Tetrahydro-n-(Phenylmethyl)- 2-Naphthalenamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.