Description

Fidarestat is a potent and selective aldose reductase inhibitor (ARI) with the CAS registry number 136087-85-9. This compound is of significant interest in pharmaceutical research and development for its potential to address diabetic complications. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic disorder therapeutics. Its mechanism targets a key enzyme in the polyol pathway, making it a critical tool for biochemical studies and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or precursor in the development of therapeutics for diabetic neuropathy and other complications.
• Biochemical Research: Used as a selective inhibitor in enzymatic studies to investigate the aldose reductase pathway and its role in cellular metabolism.
• Preclinical Drug Development: Employed in animal models and in vitro assays to evaluate efficacy and pharmacokinetics for new anti-diabetic agents.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Metabolic Disorder Studies: Applied in research focusing on the polyol pathway's impact on tissues such as nerves, kidneys, and eyes under hyperglycemic conditions.

Basic Information

Product Name	Fidarestat
CAS No.	136087-85-9
Molecular Formula	C₁₇H₁₄N₂O₄
Molecular Weight	310.31 g/mol
Synonyms	(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide; SNK-860; FK-366; Fidarestat (SNK-860); Spiro[chroman-4,4'-imidazolidine]-2-carboxamide, 6-fluoro-2',5'-dioxo-, (2S,4S)-
EINECS	Contact for details

Quality Control

Our Fidarestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.