Description

2-(Glutathione-Yl)-N,N,N',N'-Tetramethyl-4-Phenylenediamine is a specialized biochemical reagent that combines the redox-active properties of a phenylenediamine derivative with the tripeptide glutathione. This compound matters as a critical tool for researchers investigating oxidative stress, cellular redox signaling, and enzyme kinetics. It is primarily needed by scientists and manufacturers in the fields of pharmaceutical research, diagnostic assay development, and advanced biochemical studies.

Application

• Biochemical Research: Used as a substrate or probe in enzymatic assays, particularly for studying glutathione peroxidase (GPx) and other redox-related enzymes.
• Diagnostic Kits: Serves as a key chromogenic or fluorogenic component in commercial diagnostic test kits for measuring antioxidant capacity or oxidative stress markers.
• Pharmaceutical Development: Employed in drug discovery programs targeting pathways involving reactive oxygen species (ROS) and cellular defense mechanisms.
• Neuroscience Studies: Applied in research models to investigate the role of glutathione and oxidative balance in neuronal health and disease.
• Antioxidant Activity Assessment: Functions as a sensitive reagent in in vitro assays to evaluate the free radical scavenging potential of natural products or synthetic compounds.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in laboratory testing.

Basic Information

Product Name	2-(Glutathione-Yl)-N,N,N',N'-Tetramethyl-4-Phenylenediamine
CAS No.	135909-56-7
Molecular Formula	C22H35N7O6S
Molecular Weight	525.62 g/mol
Synonyms	N,N,N',N'-Tetramethyl-4-phenylenediamine glutathione conjugate; Glutathionyl-TMPD; TMPD-Glutathione adduct; 4-(Glutathion-S-yl)-N,N,N',N'-tetramethyl-1,4-phenylenediamine; 2-[(4-[(Dimethylamino)phenyl]imino]-3-[(carboxymethyl)carbamoyl]-3-[(2-[(carboxymethyl)carbamoyl]ethyl]carbamoyl]propyl] amino]ethanesulfonic acid (various tautomeric forms); Redox probe TMPD-GSH; GPx substrate analog
EINECS	Contact for details

Quality Control

Every batch of 2-(Glutathione-Yl)-N,N,N',N'-Tetramethyl-4-Phenylenediamine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the exacting requirements of research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Light yellow to brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.