Description

5-Amino-1-(2'-Deoxy-β-Ribofuranosyl)Imidazole-4-Carboxamide-5'-Triphosphate is a high-purity, chemically modified nucleoside triphosphate analog critical for advanced biochemical research and development. This compound serves as a key building block and enzymatic substrate in the synthesis and study of nucleic acids. It is primarily utilized by research institutions and pharmaceutical companies engaged in molecular biology, enzymology, and the development of novel therapeutic agents.

Application

• Enzymatic Synthesis Substrate: Used as a specialized substrate for DNA polymerases and other nucleic acid-modifying enzymes in vitro transcription and replication studies.
• Mechanistic Biochemistry Research: Essential for investigating the catalytic mechanisms and kinetics of enzymes involved in purine biosynthesis and nucleotide metabolism.
• Labeled Nucleotide Precursor: Acts as a precursor for the synthesis of radiolabeled or fluorescently tagged nucleotides for diagnostic assays and imaging.
• Antiviral & Anticancer Drug Discovery: Employed in screening and development programs for nucleoside analog-based therapeutics targeting viral polymerases or cellular replication.
• Structural Biology Studies: Used in X-ray crystallography and NMR spectroscopy to study enzyme-ligand interactions and active site architecture.
• Synthetic Biology Tool: Incorporated into engineered metabolic pathways or used to create modified nucleic acids with altered properties.

Basic Information

Item	Detail
Product Name	5-Amino-1-(2'-Deoxy-β-Ribofuranosyl)Imidazole-4-Carboxamide-5'-Triphosphate
CAS No.	133179-57-4
Molecular Formula	C13H20N6O13P3
Molecular Weight	588.25 g/mol
Synonyms	5-Aminoimidazole-4-carboxamide ribonucleotide triphosphate (AICAR triphosphate); AICA-ribotide triphosphate; ZMP triphosphate; 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5'-triphosphate; Acadesine 5'-triphosphate; AICAR 5'-triphosphate; 5-Amino-4-imidazolecarboxamide ribotide triphosphate; IMP precursor triphosphate
EINECS	Contact for details

Quality Control

Our 5-Amino-1-(2'-Deoxy-β-Ribofuranosyl)Imidazole-4-Carboxamide-5'-Triphosphate is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality protocols to guarantee reproducible performance and reliable supply for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.