Description

Dtpa-4-Aminobutane-1,1-Diphosphonate is a specialized chelating agent and bisphosphonate derivative, synthesized from diethylenetriaminepentaacetic acid (DTPA). This compound matters for its unique ability to strongly chelate metal ions, particularly lanthanides and actinides, while also exhibiting the bone-targeting properties characteristic of bisphosphonates. It is primarily needed by researchers and manufacturers in the fields of nuclear medicine, radiopharmaceuticals, and targeted drug delivery systems for diagnostic and therapeutic applications.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling antibodies, peptides, and other targeting molecules with diagnostic (e.g., 99mTc, 111In) or therapeutic (e.g., 177Lu, 225Ac) radionuclides.
• Bone-Targeted Therapeutic Agents: Serves as a building block for developing bisphosphonate-conjugated drugs designed to deliver active pharmaceutical ingredients directly to bone tissue for conditions like osteoporosis, Paget's disease, or bone metastases.
• Metal Ion Decontamination: Used in research for the chelation and removal of heavy metal or radioactive contaminants due to its high affinity for tri- and tetravalent cations.
• Contrast Agent Development: Employed in the synthesis of novel magnetic resonance imaging (MRI) contrast agents by chelating gadolinium or other paramagnetic ions.
• Chemical Research & Synthesis: Utilized as an intermediate or ligand in coordination chemistry, catalysis, and materials science research.

Basic Information

Product Name	Dtpa-4-Aminobutane-1,1-Diphosphonate
CAS No.	133049-44-2
Molecular Formula	C14H28N3O12P2
Molecular Weight	500.33 g/mol
Synonyms	DTPA-ABDP; 4-Amino-1-hydroxy-1-phosphonobutyl-DTPA; [[(Carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid, 4-amino-1-hydroxy-1,1-butanediylidene ester, P,P'-dioxide; DTPA-conjugated aminobisphosphonate; DTPA-Bisphosphonate; 2-[Bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid, 4-amino-1-hydroxy-1-phosphonobutyl ester; Aminobutane DTPA Diphosphonate
EINECS	Contact for details

Quality Control

Our Dtpa-4-Aminobutane-1,1-Diphosphonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.