Description

Thymidylylacetamido-(3'(O)-5'(C))-5'-Deoxythymidine is a specialized nucleoside analog derivative, a key building block in advanced oligonucleotide synthesis. This compound matters for its role in the development of modified antisense oligonucleotides and other therapeutic nucleic acids, where precise chemical linkage is critical for stability and efficacy. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel genetic medicines, diagnostic probes, and high-value biochemical research.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite precursor for constructing oligonucleotides with specific backbone modifications.
• Therapeutic Nucleic Acid Development: Used in the research and production of siRNA, aptamers, and other gene-silencing or targeting agents.
• Biochemical Research: Serves as a specialized monomer for studying DNA/RNA structure, function, and enzyme interactions.
• Diagnostic Probe Manufacturing: Incorporated into labeled probes for highly sensitive detection assays in molecular diagnostics.
• Pharmaceutical Intermediate: An advanced intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Thymidylylacetamido-(3'(O)-5'(C))-5'-Deoxythymidine
CAS No.	132247-55-3
Molecular Formula	C22H29N5O12
Molecular Weight	555.49 g/mol
Synonyms	5'-Deoxythymidine, 5'-O-[N-[3'-O-(thymidin-5'-yl)-5'-deoxythymidin-5'-yl]acetamido]; 3'-O-(5'-Deoxythymidin-5'-yl)-N-(thymidin-5'-yl)acetamide; Thymidylyl-(3'→5')-5'-deoxythymidine acetamide derivative; Nucleoside Dimer Acetamide; T-T Dimer Acetamide Analog; Oligonucleotide Synthesis Intermediate; CAS 132247-55-3
EINECS	Contact for details

Quality Control

Every batch of Thymidylylacetamido-(3'(O)-5'(C))-5'-Deoxythymidine is produced and tested under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical and advanced research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.