Description

6-(1-Hydroxyethyl)-2-Isopropyl-1-Oxa-Penem-3-Carboxylic Acid is a key advanced pharmaceutical intermediate belonging to the penem class of β-lactam antibiotics. This compound is critical for the synthesis of novel, broad-spectrum antibiotics designed to combat resistant bacterial strains. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on developing next-generation antibacterial therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel penem and carbapenem antibiotics.
• Antibacterial Drug Development: Used in research and development of new agents targeting drug-resistant bacteria, including MRSA and other Gram-positive pathogens.
• API (Active Pharmaceutical Ingredient) Synthesis: A key precursor in multi-step synthetic routes for producing final active drug substances.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the efficacy and pharmacokinetic profile of β-lactam compounds.
• Process Chemistry & Scale-Up: Used in developing and optimizing commercial-scale manufacturing processes for antibiotic APIs.

Basic Information

Product Name	6-(1-Hydroxyethyl)-2-Isopropyl-1-Oxa-Penem-3-Carboxylic Acid
CAS No.	132015-05-5
Molecular Formula	C12H17NO5
Molecular Weight	255.27 g/mol
Synonyms	(5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-[(1-methylethyl)thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid; 2-Isopropylthio-6-(1-hydroxyethyl)-1-oxapenem-3-carboxylic Acid; Penem Intermediate; 1-Oxapenem-3-carboxylic acid derivative; (5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-isopropylthio-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 6-(1-Hydroxyethyl)-2-Isopropyl-1-Oxa-Penem-3-Carboxylic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.