Description

Tazomeline is a selective muscarinic receptor agonist with significant research and pharmaceutical development interest. Its primary value lies in its potential for modulating cholinergic pathways, making it a critical compound for neurological and cognitive research. This high-purity intermediate is essential for pharmaceutical R&D teams, medicinal chemists, and contract manufacturing organizations (CMOs) working on next-generation central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting muscarinic receptors.
• Neurological Research: Used as a reference standard and tool compound in preclinical studies for Alzheimer's disease, schizophrenia, and other cognitive disorders.
• Medicinal Chemistry: Serves as a core scaffold for the design and development of novel M1 receptor agonists in drug discovery programs.
• Contract Manufacturing: Supplied to CMOs and CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro pharmacological profiling to assess receptor binding and functional activity.

Basic Information

Product Name	Tazomeline
CAS No.	131987-54-7
Molecular Formula	C19H21N3O2S
Molecular Weight	355.46 g/mol
Synonyms	TAZ-24; Tazomeline Hydrochloride (salt form); (3aR,4S,9bS)-4-(Ethylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole; 4-(Ethylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole; LY-287,041; M1 Agonist Tazomeline
EINECS	Contact for details

Quality Control

Every batch of Tazomeline CAS NO 131987-54-7 is manufactured and tested to meet stringent quality standards suitable for pharmaceutical research and development. We provide comprehensive analytical data to support regulatory filings. Our quality system ensures traceability and consistency, with Certificates of Analysis (COA) available for all shipments, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.