Description

Octa(Thymidine Methanephosphonate) is a specialized, high-purity oligonucleotide building block used in the synthesis of advanced nucleic acid analogs. This compound is critical for researchers and manufacturers requiring precise control over oligonucleotide structure and function, particularly for applications demanding enhanced stability and specificity. It is primarily utilized by biotechnology and pharmaceutical companies engaged in the development of therapeutic oligonucleotides, diagnostic probes, and advanced research reagents.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of antisense oligonucleotides, siRNA, and aptamers with modified backbones for improved nuclease resistance.
• Diagnostic Probe Development: Used in constructing labeled probes for fluorescence in situ hybridization (FISH), PCR, and other molecular diagnostic assays that require high binding affinity.
• Research Grade Nucleic Acids: Enables the production of custom oligonucleotides for fundamental biochemical and biophysical studies of DNA/RNA structure and protein interactions.
• Antisense Technology: Integral to creating oligonucleotides designed for sequence-specific gene silencing and modulation of gene expression in drug discovery pipelines.
• Stable Nucleic Acid Analog Production: Facilitates the manufacture of oligonucleotides with methanephosphonate linkages, which offer enhanced stability compared to standard phosphodiester bonds.

Basic Information

Product Name	Octa(Thymidine Methanephosphonate)
CAS No.	131900-31-7
Molecular Formula	C80H104N8O40P8
Molecular Weight	~2098.36 g/mol
Synonyms	Octathymidylic Acid Methanephosphonate Ester; Thymidine Octamer Methanephosphonate; Oligothymidylate Methanephosphonate (8-mer); dT8 Methanephosphonate; Octathymidine Methylphosphonate; 5'-O-Dimethoxytrityl-N-benzoyl-2'-deoxycytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite (related monomeric precursor); Oligonucleotide Phosphonate Analog
EINECS	Contact for details

Quality Control

Our Octa(Thymidine Methanephosphonate) is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and production applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and correct oligomer length. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and solvent residues is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Moisture Content (KF)	≤ 2.0%
Oligomer Length (MS)	8-mer confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.