Description

Rifalazil is a synthetic antibiotic belonging to the benzoxazinorifamycin class, developed for its potent activity against a range of bacterial pathogens. Its primary value lies in its enhanced pharmacokinetic profile and efficacy against drug-resistant strains, making it a critical compound for advanced antimicrobial research and development. This product is essential for pharmaceutical R&D laboratories, academic institutions, and manufacturers focused on developing novel antibacterial therapies, particularly for sexually transmitted infections like chlamydia.

Application

• Pharmaceutical Research & Development: Serves as a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of new antibacterial drugs.
• Antimicrobial Mechanism Studies: Used in biochemical and microbiological research to study the inhibition of bacterial RNA polymerase.
• Preclinical and Clinical Studies: Employed in the formulation of drug candidates for efficacy and safety testing in animal models and human trials.
• Reference Standard for QC: Acts as a high-purity analytical standard for quality control and assay development in pharmaceutical manufacturing.
• Synthesis of Analogues: Utilized as a core chemical scaffold for the synthetic modification and creation of novel rifamycin derivatives.

Basic Information

Product Name	Rifalazil
CAS No.	129791-92-0
Molecular Formula	C45H60N4O11
Molecular Weight	833.0 g/mol
Synonyms	KRM-1648; Benzoxazinorifamycin; ABT-1648; Rifalazil; 3'-Hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin; (3S,12Z,14E,16S,17R,18R,19R,20S,21S,22R,23S,24E)-26-(4-Isobutylpiperazin-1-yl)-5,6,21,23-tetrahydroxy-3,7,12,17,19-pentamethyl-2,8-dioxo-24-[(2S,4S,5S)-5-[(2S,5S,6R)-5-methyl-6-(prop-1-en-2-yl)oxan-2-yl]oxolane-2-yl]imino-1-oxa-9,13,16,22-tetraazapentacyclo[15.7.1.1³,¹⁵.0⁴,¹⁴.0¹⁹,²⁴]pentacosa-4,10,12,14,18,24-hexaene-25-carboxylic acid
EINECS	Contact for details

Quality Control

Our Rifalazil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.