Description

Fmoc-L-Valine n-Carboxy Anhydride is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the efficient, racemization-free incorporation of the valine residue into complex peptide chains under mild conditions. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the sequential, machine-assisted assembly of peptides using the Fmoc/t-Bu protection strategy.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Labeling: Used to introduce valine residues or Fmoc-protected handles into proteins, antibodies, or other biomolecules for further functionalization.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental reagent in university and research institute labs for studying protein structure-function relationships and peptide science.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-L-Valine n-Carboxy Anhydride
CAS No.	129288-47-7
Molecular Formula	C₂₁H₁₉NO₅
Molecular Weight	365.38 g/mol
Synonyms	Fmoc-L-Valine NCA; Fmoc-Val-NCA; N-(9-Fluorenylmethoxycarbonyl)-L-valine N-carboxyanhydride; (4S)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-methyl-2,5-dihydrofuran-2-one; Fmoc-L-valine anhydride; N-Fmoc-L-valine N-carboxy anhydride; Fmoc-Val-OCA; Nα-Fmoc-L-valine N-carboxyanhydride
EINECS	Contact for details

Quality Control

Our Fmoc-L-Valine n-Carboxy Anhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive peptide synthesis. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and optical rotation analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.