Description

Ribavirin 3',5'-Phosphate Pentadecamer Homoribopolymer is a synthetic, single-stranded oligonucleotide analog composed of fifteen ribavirin monophosphate units linked via 3',5'-phosphodiester bonds. This compound is of significant interest for its role as a potent, chain-terminating inhibitor of viral RNA-dependent RNA polymerases, offering a unique mechanism for antiviral research. It is primarily utilized by pharmaceutical R&D teams, virology research institutes, and diagnostic developers for advanced studies in antiviral drug mechanisms, viral replication assays, and the development of novel therapeutic strategies.

Application

• Antiviral Mechanism of Action Studies: Used as a specific substrate analog to investigate the inhibition of viral RNA polymerases from pathogens like hepatitis C virus (HCV), respiratory syncytial virus (RSV), and others.
• Biochemical Assay Development: Serves as a critical reagent in high-throughput screening (HTS) assays to identify and evaluate new antiviral compounds.
• Nucleic Acid Chemistry Research: Employed in studies exploring the structure-activity relationships of modified oligonucleotides and their interactions with viral enzymes.
• Reference Standard: Acts as a qualified standard for the quality control and validation of ribavirin-based antiviral formulations and diagnostic kits.
• Virology and Cell Culture Models: Applied in in vitro cell-based assays to study viral replication kinetics and the efficacy of combination therapies.

Basic Information

Product Name	Ribavirin 3',5'-Phosphate Pentadecamer Homoribopolymer
CAS No.	128583-83-5
Molecular Formula	C150H240N60O105P15
Molecular Weight	~ 4630.6 g/mol (for free acid form)
Synonyms	Ribavirin Homopolymer (15-mer); Ribavirin 15-mer Phosphodiester; 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide Pentadecamer 3',5'-Phosphate; Poly(ribavirin) (n=15); Virazole Homopolymer; Ribavirin Oligonucleotide; Antiviral Oligoribonucleotide Analog; Ribavirin MP 15-mer
EINECS	Contact for details

Quality Control

Our Ribavirin 3',5'-Phosphate Pentadecamer Homoribopolymer is manufactured under controlled conditions suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) detailing purity, oligonucleotide length verification, and endotoxin levels are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Oligonucleotide Length	15-mer (confirmed by MS)
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.