Description

Deoxycytidyl-3'-Methylphosphonate-5'-Deoxyguanidine is a specialized nucleotide analog with a modified phosphonate backbone, offering enhanced stability against enzymatic degradation. This compound is critical for advanced research and development in oligonucleotide synthesis, particularly for creating nuclease-resistant probes and therapeutic agents. It serves as a key building block for scientists and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic assay design.

Application

• Oligonucleotide Synthesis: As a modified phosphoramidite precursor for the solid-phase synthesis of antisense oligonucleotides (ASOs) and siRNA.
• Therapeutic Agent Development: Used in the research and production of nucleotide-based therapeutics targeting genetic diseases and viral infections.
• Molecular Probe Design: Enables the creation of stable, nuclease-resistant hybridization probes for diagnostic assays and fluorescence in situ hybridization (FISH).
• Biochemical Research: Serves as a tool compound for studying enzyme kinetics, particularly those involving nucleases and polymerases.
• Apitamer Development: A valuable component in the synthesis of modified aptamers with improved serum stability for diagnostic and therapeutic applications.
• Academic & Industrial R&D: Fundamental research material in universities and corporate labs focused on nucleic acid chemistry and drug discovery.

Basic Information

Product Name	Deoxycytidyl-3'-Methylphosphonate-5'-Deoxyguanidine
CAS No.	128312-31-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3'-Deoxy-3'-(methylphosphonyl)cytidylyl-(3'→5')-deoxyguanidine; d(CpMe)G; Cytidylyl-(3'→5')-deoxyguanidine, 3'-deoxy-3'-(methylphosphonyl)-; Nucleotide Phosphonate Dimer; Methylphosphonate-linked Dinucleotide; Anti-sense Oligonucleotide Intermediate; Modified Dinucleotide
EINECS	Contact for details

Quality Control

Our Deoxycytidyl-3'-Methylphosphonate-5'-Deoxyguanidine is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. All batches are analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.