Description

S-(-)-Naftopidil is the pharmacologically active enantiomer of the α-1 adrenoceptor antagonist naftopidil. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in the study of selective receptor interactions. It serves as a key intermediate and reference standard for the synthesis and analytical validation of enantiomerically pure active pharmaceutical ingredients (APIs). Target industries include pharmaceutical R&D, contract manufacturing organizations (CMOs), and academic research institutions focusing on urology and cardiovascular therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method development in API manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical chiral building block in the synthesis of enantiomerically pure naftopidil and related compounds.
• Biochemical Research: Employed in vitro and in vivo studies to investigate the specific pharmacological profile and metabolic pathways of the S-enantiomer.
• Method Development and Validation: Essential for developing and calibrating chiral analytical methods such as HPLC and LC-MS.
• Preclinical Studies: Used in animal models to assess the efficacy and safety profile of the isolated enantiomer.

Basic Information

Product Name	S-(-)-Naftopidil
CAS No.	127931-16-2
Molecular Formula	C₂₄H₂₈N₂O₃
Molecular Weight	392.49 g/mol
Synonyms	(S)-Naftopidil; (-)-Naftopidil; S-Naftopidil; (S)-4-(2-Methoxyphenyl)-α-[[(2R)-1,2,3,4-tetrahydro-2-naphthalenyl]amino]methyl]-1-piperazineethanol; Flivas; Avishot; Naftopidil S-enantiomer
EINECS	Contact for details

Quality Control

Our S-(-)-Naftopidil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.