Description

R-(+)-Naftopidil CAS NO 127931-15-1 is the pharmacologically active enantiomer of the α-1 adrenergic receptor antagonist naftopidil. This high-purity chiral compound is critical for pharmaceutical research and development, particularly in the study of selective receptor interactions and the development of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in urology, cardiovascular, and neuropharmacology research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure naftopidil and related therapeutic compounds.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies to investigate the specific activity of the R-enantiomer at α-1 adrenergic receptor subtypes.
• Analytical Standard: Employed in method development and quality control (HPLC, GC) for the quantification and purity assessment of naftopidil in bulk substances and finished dosage forms.
• Preclinical Development: Essential for pharmacokinetic, pharmacodynamic, and toxicology studies during the early-stage development of new chemical entities targeting adrenergic pathways.
• Academic Research: Supports fundamental research in medicinal chemistry and pharmacology focused on stereoselectivity and drug-receptor interactions.

Basic Information

Product Name	R-(+)-Naftopidil
CAS No.	127931-15-1
Molecular Formula	C₂₄H₂₈N₂O₃
Molecular Weight	392.49 g/mol
Synonyms	(+)-Naftopidil; (R)-Naftopidil; R-Naftopidil; (R)-(+)-Naftopidil; Naftopidil R enantiomer; Naftopidil, (R)-; Flivas; Avishot; 4-(2-Methoxyphenyl)-α-[[(2R)-1,4-benzodioxan-2-yl]methyl]-1-piperazineethanol
EINECS	Contact for details

Quality Control

Our R-(+)-Naftopidil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.