Description

Rifapentine Hydrochloride is a semi-synthetic antibiotic belonging to the rifamycin class, specifically formulated as its hydrochloride salt for enhanced stability and handling. This compound is of critical importance in the global fight against tuberculosis, offering a potent mechanism of action against *Mycobacterium tuberculosis*. It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing and producing advanced anti-tuberculosis therapies, particularly for long-acting treatment regimens.

Application

• Active Pharmaceutical Ingredient (API): Core component in the formulation of anti-tuberculosis (TB) drugs, especially for intermittent or once-weekly therapy protocols.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to develop new TB treatment combinations and evaluate efficacy against drug-resistant strains.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or other chromatographic methods to assay commercial drug products.
• Mechanistic Studies: Employed in biochemical research to study the inhibition of bacterial DNA-dependent RNA polymerase.
• Formulation Development: Utilized in the development of various dosage forms, including tablets and capsules, optimizing for bioavailability and stability.

Basic Information

Product Name	Rifapentine Hydrochloride
CAS No.	127923-87-9
Molecular Formula	C47H64ClN3O12 • HCl
Molecular Weight	877.00 g/mol (for the hydrochloride salt)
Synonyms	Rifapentine HCl; 3-[[(4-Cyclopentyl-1-piperazinyl)imino]methyl]rifamycin SV hydrochloride; Rifapentine monohydrochloride; Priftin (brand name, as drug substance); Antibiotic DL 473-IT; KRM-1648 hydrochloride; (3S,12Z,14E,16S,17R,18R,19R,20R,21S,22R,23S,24E)-26-(Cyclopentylamino)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,12,16,18,20,22-heptamethyl-9-oxo-1,15-dioxa-10(1,3)-pyridina-7(4,1)-oxepana-11(1,3)-benzenacyclooctadecaphan-8-ylideneaminooxyformaldehyde hydrochloride
EINECS	Contact for details

Quality Control

Our Rifapentine Hydrochloride is manufactured and tested under a strict quality management system. We offer material suitable for pharmaceutical development, with specifications aligned with industry standards for high-purity active ingredients. Comprehensive testing includes identity, purity, and impurity profile analysis. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	Reddish-brown to dark red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%
Microbial Enumeration	Meets Ph. Eur./USP criteria for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.