Description

Aureobasidin E is a potent cyclic depsipeptide antifungal agent originally isolated from the filamentous fungus *Aureobasidium pullulans*. This compound is valued for its specific and high-affinity inhibition of fungal inositol phosphorylceramide synthase, a key enzyme in sphingolipid biosynthesis. It serves as a critical reference standard and research-grade biochemical for pharmaceutical R&D, microbiology, and antifungal mechanism studies.

Application

• Pharmaceutical Research & Development: As a reference standard in the discovery and screening of novel antifungal agents.
• Mechanistic Studies: Used to investigate fungal sphingolipid metabolism and the role of inositol phosphorylceramide synthase in fungal cell viability.
• Microbiology & Mycology: A tool compound for studying fungal pathogenesis, resistance mechanisms, and for in vitro antifungal susceptibility testing.
• Biochemical Assay Development: Serves as a key inhibitor in enzymatic assays to validate new screening platforms for antifungal activity.
• Academic Research: Utilized in university and institutional labs for fundamental research on fungal biology and membrane biochemistry.

Basic Information

Product Name	Aureobasidin E
CAS No.	127785-66-4
Molecular Formula	C61H91N9O13
Molecular Weight	1150.4 g/mol
Synonyms	Aureobasidin E; Antibiotic A 192411.2; AbA E; Cyclo[(2R,4R)-2-hydroxy-4-methylpentanoyl-L-phenylalanyl-N-methyl-L-valyl-N-methyl-L-valyl-(3R)-3-hydroxy-N,2-dimethyl-L-leucyl-N-methyl-L-valyl-N-methyl-L-valyl-(3R)-3-hydroxy-N,2-dimethyl-L-leucyl-N-methyl-L-valyl-N-methyl-L-valyl]; Aureobasidin A derivative
EINECS	Contact for details

Quality Control

Every batch of Aureobasidin E is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research and reference standard requirements. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.