Description

2,2-Difluoro-1,3-Benzodioxole-4-Carboxylic Acid is a high-value fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine atoms and a carboxylic acid functional group, enabling precise modifications to molecular properties such as metabolic stability, lipophilicity, and binding affinity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorobenzodioxole moiety can enhance biological activity and environmental profile.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Fluorine Chemistry & Catalysis: Employed as a model substrate in methodological studies for novel fluorination reactions and cross-coupling catalysis development.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2,2-Difluoro-1,3-Benzodioxole-4-Carboxylic Acid
CAS No.	126120-85-2
Molecular Formula	C8H4F2O4
Molecular Weight	202.11 g/mol
Synonyms	4-Carboxy-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid; 1,3-Benzodioxole-4-carboxylic acid, 2,2-difluoro-; Difluorobenzodioxole carboxylic acid; DFBD-CA; 2,2-Difluorobenzodioxole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1,3-Benzodioxole-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.