Description

3-[[6-(Trifluoromethyl)-2H-1,2,4-Benzothiadiazine 1,1-Dioxide]-3-Ylthio]Propanoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzothiadiazine dioxide core and trifluoromethyl substituent. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted bioactivity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, including potential candidates for metabolic and central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for research and commercial production.
• Drug Discovery & Development: Used in medicinal chemistry for the design and optimization of new chemical entities, particularly those targeting specific enzyme pathways.
• Metabolic Disorder Research: Serves as a precursor in the development of potential therapeutic agents for diabetes and related metabolic syndromes.
• CNS Drug Candidates: Employed in the research of central nervous system (CNS) targeting pharmaceuticals due to its specific molecular architecture.
• Chemical Biology Probes: Utilized as a specialized scaffold for creating probes to study biological mechanisms and protein interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Product Name	3-[[6-(Trifluoromethyl)-2H-1,2,4-Benzothiadiazine 1,1-Dioxide]-3-Ylthio]Propanoic Acid
CAS No.	124850-88-0
Molecular Formula	C11H9F3N2O4S2
Molecular Weight	354.32 g/mol
Synonyms	3-[(6-(Trifluoromethyl)-1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)thio]propanoic acid; 3-((6-(Trifluoromethyl)-1,1-dioxido-2H-benzo[e][1,2,4]thiadiazin-3-yl)thio)propanoic acid; 124850-88-0; Propanoic acid, 3-[[6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-3-thione 1,1-dioxide]thio]-; Benzothiadiazine propanoic acid derivative; Trifluoromethyl benzothiadiazine dioxide intermediate
EINECS	Contact for details

Quality Control

Our 3-[[6-(Trifluoromethyl)-2H-1,2,4-Benzothiadiazine 1,1-Dioxide]-3-Ylthio]Propanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.