Description

Benzoyl Fluoride, 3-(Difluoromethoxy)- (9Ci) CAS NO 123876-16-4 is a specialized fluorinated aromatic compound, serving as a high-value building block in advanced organic synthesis. Its unique structure, featuring both a benzoyl fluoride and a difluoromethoxy group, makes it a critical reagent for introducing fluorinated motifs into target molecules, which is essential for modulating the physicochemical properties of advanced materials and active pharmaceutical ingredients. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for the development of novel compounds with enhanced stability, bioavailability, and performance.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems to improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoromethoxy group can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine atoms into polymer backbones or side chains, resulting in materials with enhanced chemical resistance, lower surface energy, and improved weatherability.
• Fluorinated Dye & Pigment Production: Acts as a building block for creating fluorinated chromophores used in high-performance dyes and pigments for specialized applications.
• Organic Synthesis Reagent: A versatile reagent in research laboratories for nucleophilic aromatic substitution and cross-coupling reactions to construct complex, fluorinated molecular architectures.

Basic Information

Product Name	Benzoyl Fluoride, 3-(Difluoromethoxy)- (9Ci)
CAS No.	123876-16-4
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	3-(Difluoromethoxy)benzoyl Fluoride; m-(Difluoromethoxy)benzoyl Fluoride; Benzoyl Fluoride, 3-(Difluoromethoxy)-; 3-Difluoromethoxybenzoyl Fluoride; 1-(Difluoromethoxy)-3-fluorocarbonylbenzene; (3-(Difluoromethoxy)phenyl)(fluoro)methanone
EINECS	Contact for details

Quality Control

Every batch of Benzoyl Fluoride, 3-(Difluoromethoxy)- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic pathway. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by GC/HPLC), identity (IR, NMR), and impurity profiles. Our quality commitment ensures reliable batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and reacts with strong bases; ensure the container is kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.