Description

N(2),3-Ethenodeoxyguanosine 5'-Phosphate is a modified nucleoside phosphate derivative, a critical building block in nucleic acid chemistry and biochemical research. This compound is valued for its role in studying DNA adduct formation, oxidative stress, and mutagenesis, providing essential insights into molecular biology and toxicology. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on advanced nucleotide synthesis and biomarker discovery.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies related to DNA repair mechanisms and nucleotide metabolism.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of novel nucleotide analogs for potential therapeutic applications.
• Toxicology Studies: Employed to investigate the formation and repair of specific etheno-DNA adducts, which are biomarkers of oxidative stress and lipid peroxidation.
• Diagnostic Assay Development: Utilized in the development of sensitive detection methods (e.g., ELISA, LC-MS/MS) for DNA damage biomarkers.
• Academic Research: Fundamental tool for universities and research institutes exploring the structural and functional impact of DNA modifications.
• Reference Standard: Acts as a high-purity certified reference material (CRM) for analytical method validation and quality control in laboratories.

Basic Information

Product Name	N(2),3-Ethenodeoxyguanosine 5'-Phosphate
CAS No.	121055-52-5
Molecular Formula	C12H14N5O7P
Molecular Weight	371.24 g/mol
Synonyms	1,N2-Etheno-2'-deoxyguanosine 5'-monophosphate; 1,N2-Etheno-dGMP; ε-dGMP; 1,N2-Etheno-2'-deoxyguanosine 5'-(dihydrogen phosphate); 3,N2-Etheno-2'-deoxyguanosine 5'-monophosphate; N2,3-Etheno-2'-deoxyguanosine 5'-phosphate; 1,N2-Ethenoguanine deoxyribonucleotide
EINECS	Contact for details

Quality Control

Our N(2),3-Ethenodeoxyguanosine 5'-Phosphate is manufactured under strict quality protocols suitable for research and analytical applications. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.