Description

Polydeoxyguanylic-Polydeoxycytidylic Acid Sodium Salt is a synthetic, double-stranded oligonucleotide complex composed of deoxyguanylic and deoxycytidylic acid residues. This compound is a critical research-grade biochemical used as a potent immunostimulant and a defined nucleic acid structure for molecular biology studies. It is essential for researchers and developers in the fields of immunology, vaccine adjuvants, and nucleic acid-based therapeutics who require a high-purity, well-characterized toll-like receptor (TLR) agonist.

Application

• Immunological Research: Used as a potent agonist for Toll-like Receptor 9 (TLR9) to study innate immune responses, dendritic cell maturation, and cytokine production.
• Vaccine Adjuvant Development: Serves as a key component in preclinical research for novel vaccine formulations to enhance antigen-specific immune responses.
• Cancer Immunotherapy Studies: Employed in experimental models to investigate immunostimulatory effects and potential anti-tumor activity.
• Nucleic Acid Structure & Interaction Studies: Provides a defined double-stranded DNA (dsDNA) model for investigating protein-DNA interactions, enzyme kinetics, and nucleic acid stability.
• Cell Culture & In Vitro Assays: Used to stimulate immune cells in culture for functional assays and mechanistic studies of immune signaling pathways.
• Autoimmune Disease Research: Applied in experimental models to understand the role of TLR9 signaling in autoimmune disorders.

Basic Information

Item	Detail
Product Name	Polydeoxyguanylic-Polydeoxycytidylic Acid Sodium Salt
CAS No.	119039-74-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(dG-dC); Poly(dG-dC) Sodium Salt; Poly(deoxyguanylic-deoxycytidylic) Acid Sodium Salt; Poly(dG)-Poly(dC); dG-dC Copolymer; TLR9 Agonist (dsDNA); Oligodeoxynucleotide Complex; Synthetic Double-Stranded DNA
EINECS	Contact for details

Quality Control

Our Polydeoxyguanylic-Polydeoxycytidylic Acid Sodium Salt is produced under stringent conditions to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, endotoxin testing, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccant in the storage container.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Endotoxin Level	< 10 EU/mg
Absorbance Ratio (A260/A280)	1.8 - 2.0
Solubility	Soluble in sterile water or TE buffer
Chain Length	Defined range (e.g., 20-30 base pairs)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.