Description

Polyinosinic-Uridylic Acid Potassium is a synthetic double-stranded RNA complex, a potassium salt of polyinosinic-polycytidylic acid. This compound is a potent immunostimulant and interferon inducer, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by biotechnology and pharmaceutical companies engaged in the development of antiviral therapeutics, vaccine adjuvants, and immunology research.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of advanced immunomodulatory drugs.
• Immunology Research: Used as a toll-like receptor 3 (TLR3) agonist to study innate immune responses, cytokine production, and dendritic cell maturation in vitro.
• Vaccine Adjuvant Development: Investigated for its potential to enhance the efficacy of vaccines by stimulating a stronger and more targeted immune response.
• Antiviral Agent Research: Employed in preclinical studies to evaluate its efficacy against a range of viral infections due to its interferon-inducing properties.
• Cell Culture & Signaling Studies: Applied in laboratory settings to activate specific intracellular signaling pathways related to viral defense mechanisms.
• Biochemical Reagent: Functions as a high-purity reagent in molecular biology and biochemistry for specialized assays and experimental protocols.

Basic Information

Product Name	Polyinosinic-Uridylic Acid Potassium
CAS No.	118539-78-9
Molecular Formula	(C10H12N4O8P2·C9H11N2O8P2)n·xK
Molecular Weight	Variable (Polymer)
Synonyms	Poly I:Poly C, Potassium Salt; Polyinosinic-Polycytidylic Acid Potassium Salt; Poly I:C Potassium; pIC Potassium; Poly(I)·Poly(C) Potassium; TLR3 Agonist (Poly I:C K+); Polynosinic Acid-Polycytidylic Acid Potassium Complex
EINECS	Contact for details

Quality Control

Our Polyinosinic-Uridylic Acid Potassium is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including spectroscopic identification, purity assay, and endotoxin level checks, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Water Content (KF)	< 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.