Description

4-(Fluoromethyl)Benzoic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic introduction of a fluoromethyl group onto a benzoic acid scaffold, enabling precise modulation of molecular properties such as lipophilicity, metabolic stability, and binding affinity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances bioactivity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and stability.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in coupling reactions (e.g., Suzuki, Heck) and as a precursor for other fluorinated aromatic derivatives in academic and industrial R&D.
• Fluorinated Probe Development: Utilized in the synthesis of biochemical probes and PET (Positron Emission Tomography) tracer molecules for diagnostic imaging.

Basic Information

Product Name	4-(Fluoromethyl)Benzoic Acid
CAS No.	118507-45-2
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	p-(Fluoromethyl)benzoic acid; 4-Fluoromethylbenzoic acid; Benzoic acid, 4-(fluoromethyl)-; 4-Carboxybenzyl fluoride; (4-Carboxyphenyl)methyl fluoride; p-Carboxybenzyl fluoride; α-Fluoro-p-toluic acid; 4-Fluoromethyl-benzoic acid
EINECS	Contact for details

Quality Control

Our production of 4-(Fluoromethyl)Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure consistency and compliance with customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support development projects by offering material produced under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.