Description

8,5'(S)-Cyclo-2'-Deoxyadenosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. This compound is valued for its unique cyclized structure, which imparts specific properties useful in studying DNA damage, repair mechanisms, and as a precursor for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, nucleotide chemistry, and the development of targeted molecular probes.

Application

• Pharmaceutical Intermediate: Serves as a critical synthetic precursor in the development of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Research: Used as a specialized substrate or standard in enzymatic studies related to DNA repair pathways, particularly those involving cyclopurine lesions.
• Analytical Reference Standard: Employed as a high-purity certified reference material (CRM) in LC-MS, HPLC, and other analytical methods for quantifying DNA adducts and related compounds.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies aimed at designing new molecules with enhanced biological activity or stability.
• Academic Research: Fundamental tool in universities and research labs for investigating the mechanisms of oxidative DNA damage and its biological consequences.

Basic Information

Product Name	8,5'(S)-Cyclo-2'-Deoxyadenosine
CAS No.	117182-88-4
Molecular Formula	C10H11N5O3
Molecular Weight	249.23 g/mol
Synonyms	8,5'-Cyclo-2'-deoxyadenosine (S-isomer); (5'S)-8,5'-Cyclo-2'-deoxyadenosine; 8,5'-cA; 8,5'-Cyclo-dA; 8,5'-Cyclopurine-2'-deoxynucleoside; 8,5'-cA (S); 8,5'-Cyclo-2'-deoxyadenosine (5'S); 5',8-Cyclo-2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Every batch of 8,5'(S)-Cyclo-2'-Deoxyadenosine is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.