Description

(+)-U-50488 Hydrochloride CAS NO 114528-81-3 is a high-purity, enantiomerically pure chemical compound widely recognized as a potent and selective κ-opioid receptor (KOR) agonist. This specificity makes it an invaluable pharmacological tool for neuroscience research, enabling the study of pain pathways, addiction mechanisms, and neuropsychiatric disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and basic neuropharmacology.

Application

• Pharmacological Research Tool: Used as a selective κ-opioid receptor agonist in in vitro and in vivo studies to investigate KOR signaling and function.
• Neuroscience & Pain Research: Critical for studying the role of the κ-opioid system in pain modulation, analgesia, and the development of non-addictive pain therapeutics.
• Psychiatric Disorder Models: Employed in preclinical research to model and understand depression, anxiety, and stress-related behaviors mediated by dynorphin/KOR pathways.
• Addiction & Substance Abuse Research: A key compound for exploring the effects of KOR activation on dopamine release and reward circuitry, relevant to addiction mechanisms.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the discovery of novel KOR-targeting pharmaceuticals.
• Biochemical Assay Development: Used to validate and calibrate assays for receptor binding, functional activity (e.g., GTPγS), and high-throughput screening (HTS).

Basic Information

Item	Detail
Product Name	(+)-U-50488 Hydrochloride
CAS No.	114528-81-3
Molecular Formula	C15H23ClN2O2 • HCl
Molecular Weight	345.27 g/mol
Synonyms	(+)-U-50488; U-50488 Hydrochloride; (3R,4R)-(+)-trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide Hydrochloride; (3R,4R)-U-50488 Hydrochloride; U-50488H; U-50488 HCl; Kappa Opioid Receptor Agonist U-50488; (+)-trans-U-50488 Hydrochloride
EINECS	Contact for details

Quality Control

Our (+)-U-50488 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, enantiomeric excess, and identity confirmation. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, water content (KF), residue on ignition, and other relevant parameters are available upon request to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.