Description

1-(4-Fluorophenyl)-1H-Imidazole-4-Carboxylic Acid is a high-purity, versatile heterocyclic building block of significant importance in advanced organic synthesis. This compound is valued for its unique molecular structure, which incorporates both a fluorinated aromatic ring and an imidazole-carboxylic acid moiety, making it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex molecules, including potential kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging the bioactivity of the fluorophenyl-imidazole scaffold.
• Chemical Research & Development: Serves as a versatile precursor in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal-catalyzed reactions or as a core structure in organocatalysts.
• Material Science: Potential monomer or additive for synthesizing advanced polymers with specific electronic or thermal properties.

Basic Information

Product Name	1-(4-Fluorophenyl)-1H-Imidazole-4-Carboxylic Acid
CAS No.	114067-97-9
Molecular Formula	C10H7FN2O2
Molecular Weight	206.18 g/mol
Synonyms	4-Fluoro-1H-imidazole-1-benzoic acid; 1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acid; 4-Carboxy-1-(4-fluorophenyl)imidazole; 1H-Imidazole-4-carboxylic acid, 1-(4-fluorophenyl)-; 4-Fluorophenylimidazole-4-carboxylic acid; FPI-4-COOH; 4-Fluoro-1-(1H-imidazol-4-yl)benzoic acid (tautomeric form).
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)-1H-Imidazole-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.