Description

4-Benzyloxy-2-Fluorobenzoic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals, where the introduction of fluorine and benzyl-protected oxygen functionalities can dramatically alter biological activity and metabolic stability. Industrial and research chemists in the pharmaceutical, agrochemical, and material science sectors require this precise chemical for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting fluorinated small molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances product efficacy and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for Suzuki-Miyaura and other cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution on aromatic system reactivity and physical properties.

Basic Information

Product Name	4-Benzyloxy-2-Fluorobenzoic Acid
CAS No.	114045-96-4
Molecular Formula	C₁₄H₁₁FO₃
Molecular Weight	246.24 g/mol
Synonyms	2-Fluoro-4-(phenylmethoxy)benzoic Acid; Benzoic acid, 2-fluoro-4-(phenylmethoxy)-; 4-(Benzyloxy)-2-fluorobenzoic Acid; 2-Fluoro-4-benzyloxybenzoic Acid; 4-Benzyloxy-2-fluorobenzoic Acid; 4-(Benzyloxy)-2-fluorobenzoic acid; 2-Fluoro-4-(benzyloxy)benzoic acid; 4-O-Benzyl-2-fluorobenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2-Fluorobenzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and advanced material applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0 - 103.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.