Description

3'(2')-o-(4-Benzoylbenzoyl)-1,N(6)-Ethenoadenosine 5'-Diphosphate is a chemically modified nucleotide analog designed for advanced biochemical research and development. This compound is a critical tool for studying purinergic signaling pathways, particularly as a potent and specific antagonist for P2X and P2Y receptor subtypes. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers engaged in neuroscience, cardiovascular research, and inflammation studies. Its unique etheno-bridged structure provides enhanced stability and specificity for probing ATP-mediated cellular processes.

Application

• Biochemical Research: As a high-affinity antagonist for P2X1, P2X3, and other P2 receptor subtypes in mechanistic studies of purinergic signaling.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) assays to identify and characterize novel modulators of purinergic receptors for drug discovery.
• Neuroscience: Investigation of ATP's role in synaptic transmission, neuropathic pain, and neurodegenerative conditions.
• Cardiovascular Research: Studying the regulation of vascular tone, platelet aggregation, and cardiac function mediated by extracellular nucleotides.
• Inflammation & Immunology: Probing the involvement of purinergic receptors in immune cell activation and inflammatory responses.
• Diagnostic Development: Serving as a reference standard or key component in assay kits for receptor binding studies and functional cellular assays.
• Enzymology: Potential use as a substrate analog or inhibitor in studies of nucleotide-metabolizing enzymes like ecto-nucleotidases.

Basic Information

Product Name	3'(2')-o-(4-Benzoylbenzoyl)-1,N(6)-Ethenoadenosine 5'-Diphosphate
CAS No.	110682-84-3
Molecular Formula	C31H27N5O14P2
Molecular Weight	755.52 g/mol
Synonyms	Bz-ATP, e-ATP; 1,N6-Etheno-2'(3')-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate; BzATP; 3'-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate; Bz-2'(3')-O-(4-Benzoylbenzoyl)adenosine 5'-triphosphate; P2X Receptor Antagonist; Etheno-ATP analog; 2'(3')-O-(4-Benzoylbenzoyl)-1,N6-ethenoadenosine 5'-triphosphate
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical is governed by a rigorous quality management system. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), water content, and functional assay data is provided with every shipment to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider aliquoting under an inert atmosphere to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Biological Activity	Functional activity confirmed in cell-based assay (Data on COA)
Solubility	Soluble in DMSO, aqueous buffer (pH ~7)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.