Description

2,2-Difluorocyclopropanecarboxylic Acid is a specialized fluorinated cyclopropane derivative that serves as a high-value synthetic building block. Its unique structure, featuring a strained cyclopropane ring and two fluorine atoms, makes it a critical intermediate for introducing conformational rigidity and fluorinated motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. It enables the synthesis of novel compounds with potential applications in drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluorocyclopropane unit can enhance biological activity and environmental stability.
• Material Science Research: Employed in the creation of advanced polymers and liquid crystals, where the fluorinated cyclopropane structure can modify physical properties like thermal stability and dielectric constant.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Fluorine Chemistry Research: Acts as a model compound for studying the reactivity and stereochemistry of fluorinated small rings in academic and industrial R&D settings.
• Peptidomimetics Development: Incorporated into peptide analogs to enhance metabolic stability and membrane permeability by mimicking natural amino acid side chains.

Basic Information

Product Name	2,2-Difluorocyclopropanecarboxylic Acid
CAS No.	107873-03-0
Molecular Formula	C4H4F2O2
Molecular Weight	122.07 g/mol
Synonyms	2,2-Difluorocyclopropane-1-carboxylic Acid; 1-Carboxy-2,2-difluorocyclopropane; Difluorocyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2,2-difluoro-; 2,2-Difluoro-1-cyclopropanecarboxylic acid; 107873-03-0
EINECS	Contact for details

Quality Control

Our 2,2-Difluorocyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant regulatory frameworks for pharmaceutical and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases, oxidizing agents, and reactive metals. Ensure containers are kept upright to prevent leakage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.