Description

(S)-Tamsulosin Hydrochloride CAS NO 106463-19-8 is the pharmacologically active enantiomer of the widely used α-1 adrenergic receptor antagonist. This high-purity chiral intermediate is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is essential for pharmaceutical manufacturers and advanced research institutions focused on developing and producing targeted urological therapeutics, particularly for the treatment of benign prostatic hyperplasia (BPH).

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key chiral building block in the commercial production of enantiopure tamsulosin hydrochloride.
• Pharmaceutical R&D: Serves as a critical reference standard and starting material for developing new formulations and drug delivery systems for α-blockers.
• Generic Drug Manufacturing: Essential for companies producing generic versions of BPH medications requiring the pure (S)-enantiomer for efficacy and regulatory compliance.
• Pharmacological Studies: Used in preclinical and clinical research to study the specific binding and effects of the (S)-enantiomer on adrenergic receptors.
• Quality Control & Analytical Testing: Employed as an analytical reference standard in HPLC, LC-MS, and other methods to assay drug products and ensure enantiomeric purity.

Basic Information

Product Name	(S)-Tamsulosin Hydrochloride
CAS No.	106463-19-8
Molecular Formula	C20H28N2O5S • HCl
Molecular Weight	444.98 g/mol
Synonyms	(S)-5-[2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride; (R)-(-)-Tamsulosin Hydrochloride; Tamsulosin (S)-Isomer Hydrochloride; YM-12617; Flomax (S-enantiomer); (S)-Tamsulosin HCl; (2S)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Tamsulosin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.