Description

(+)-Tamsulosin CAS NO 106138-88-9 is the pharmacologically active enantiomer of tamsulosin, a high-purity sulfonamide derivative. This compound is of critical importance as a key chiral intermediate and reference standard in the development and quality control of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and analytical service providers focused on urological therapeutics, specifically for the production of enantiopure tamsulosin hydrochloride.

Application

• Pharmaceutical Intermediate: Serves as the crucial chiral building block for the synthesis of the enantiomerically pure active pharmaceutical ingredient, (R)-(-)-Tamsulosin Hydrochloride.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical manufacturing.
• Research & Development: Essential for preclinical and clinical studies investigating the pharmacology, metabolism, and safety profile of the single enantiomer.
• Process Chemistry: Employed in the development and optimization of asymmetric synthesis routes and chiral separation processes.
• Regulatory Submissions: Provides the necessary high-purity material for stability studies and documentation required by regulatory agencies (e.g., FDA, EMA).
• Impurity Profiling: Acts as a standard for identifying and quantifying the undesired enantiomer and related substances in final drug products.

Basic Information

Product Name	(+)-Tamsulosin
CAS No.	106138-88-9
Molecular Formula	C20H28N2O5S
Molecular Weight	408.51 g/mol
Synonyms	(R)-(+)-Tamsulosin; (+)-(R)-5-[2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide; (R)-Tamsulosin; Tamsulosin Enantiomer; (R)-(-)-Tamsulosin Free Base (enantiomer); ABBOTT-70085; YM-12617-1
EINECS	Contact for details

Quality Control

Our (+)-Tamsulosin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure compliance with stringent in-house specifications suitable for pharmaceutical R&D and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) for long-term storage to prevent degradation. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.