Description

4-(Difluoromethoxy)Cinnamicacid is a high-purity fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy substituent imparts distinct electronic and steric properties, making it a valuable intermediate for creating novel compounds with enhanced biological activity and material characteristics. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty materials sectors seeking to incorporate fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and anticancer research programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and plant growth regulators where the difluoromethoxy group can improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where fluorine atoms enhance performance and stability.
• Polymer Modification: Incorporated as a monomer or additive to engineer specialty polymers with specific thermal, chemical, or surface properties.
• Chemical Research & Development: A versatile reagent for medicinal chemistry, exploring structure-activity relationships (SAR) and developing new fluorination methodologies.
• Fluorinated Probe Synthesis: Used in life sciences to create fluorescent dyes, imaging agents, or biochemical probes with modified lipophilicity and cell permeability.

Basic Information

Product Name	4-(Difluoromethoxy)Cinnamicacid
CAS No.	103962-07-8
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	(E)-3-[4-(Difluoromethoxy)phenyl]acrylic acid; 4-(Difluoromethoxy)cinnamic acid; trans-4-(Difluoromethoxy)cinnamic acid; 3-(4-(Difluoromethoxy)phenyl)-2-propenoic acid; α,β-Unsaturated carboxylic acid derivative; DFM-Cinnamic Acid; 4-DFM-CA
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Cinnamicacid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) documenting all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.