Description

2,5-Difluoro-4-Methylbenzoic Acid is a fluorinated benzoic acid derivative serving as a versatile and critical building block in advanced organic synthesis. This compound matters for its role in introducing both fluorine atoms and a carboxylic acid functional group into complex molecular architectures, enabling the fine-tuning of physical, chemical, and biological properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as in materials science for developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates where fluorine substitution can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence of the final product.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystals for advanced display technologies (LCDs), where the difluoro-methylbenzoic acid core contributes to desired dielectric anisotropy and thermal stability.
• Polymer Modification: Serves as a monomer or modifier in the production of specialty polymers, including high-performance polyesters and polyamides, to alter thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, esterifications, and amide bond formations as a readily functionalized aromatic carboxylic acid.
• Chemical Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2,5-Difluoro-4-Methylbenzoic Acid
CAS No.	103877-80-1
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	4-Methyl-2,5-difluorobenzoic Acid; 2,5-Difluoro-p-toluic Acid; Benzoic acid, 2,5-difluoro-4-methyl-; 2,5-Difluoro-4-methyl-benzoic acid; 2,5-Difluoro-4-toluic acid; 4-Methyl-2,5-difluorobenzoic acid; 103877-80-1; 2,5-Difluoro-4-methylbenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-Methylbenzoic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.