Description

3,5-Difluoro-4-Methylbenzoic Acid is a high-purity fluorinated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a methyl group on the aromatic ring, which are essential for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and plant growth regulators where the difluoromethyl benzoate moiety imparts enhanced bioactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores that improve the thermal stability, dielectric anisotropy, and luminescent efficiency of electronic display materials.
• Polymer Modification: Incorporated as a monomer or additive to engineer specialty polymers with improved chemical resistance, weatherability, and surface properties.
• Organic Synthesis Building Block: Employed in Suzuki-Miyaura cross-coupling, esterification, and amidation reactions to introduce a sterically defined, fluorinated aromatic unit.
• Chemical Research & Development: Essential for academic and industrial research exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	3,5-Difluoro-4-Methylbenzoic Acid
CAS No.	103877-76-5
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	4-Methyl-3,5-difluorobenzoic Acid; 3,5-Difluoro-p-toluic Acid; Benzoic acid, 3,5-difluoro-4-methyl-; 3,5-Difluoro-4-methyl-benzoic acid; 103877-76-5; 4-Methyl-3,5-difluorobenzoic acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methylbenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.