Description

2-Chloro-5-Fluoro-4-Methyl-Benzoic Acid is a high-purity, multi-functional aromatic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen and methyl substituents on the benzoic acid core, which enables precise structural modifications for developing novel compounds. This intermediate is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new active ingredients with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules with potential anti-inflammatory, anti-cancer, or central nervous system activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro-methyl substitution pattern can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing complex organic molecules used in electronic displays and optoelectronic devices.
• Polymer & Resin Modifier: Incorporated to introduce specific functional groups into polymer chains, altering physical properties like thermal stability, solubility, or reactivity.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and esterification/amide formation to construct more complex molecular architectures in R&D settings.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where halogen atoms influence color fastness and spectral properties.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Methyl-Benzoic Acid
CAS No.	103877-61-8
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-Chloro-5-fluoro-4-methylbenzoic acid; 4-Methyl-2-chloro-5-fluorobenzoic acid; Benzoic acid, 2-chloro-5-fluoro-4-methyl-; 2-Chloro-5-fluoro-p-toluic acid; 5-Fluoro-2-chloro-4-methylbenzoic acid; 4-Methyl-5-fluoro-2-chlorobenzoic acid; 103877-61-8 (CAS); 2-Cl-5-F-4-Me-BA
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Methyl-Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings for pharmaceutical or agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade) ≥99.0% (High Purity Grade)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.