Description

n-(4-Azido-3-Iodosalicyl)-N'-β-Aminoethylvindesine is a specialized, high-potency chemical derivative of vindesine, a vinca alkaloid. This compound is primarily valued as a critical intermediate or active component in advanced pharmaceutical research and development. It is essential for researchers and manufacturers in the fields of oncology and targeted drug delivery, particularly for the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates. Its unique structure, incorporating both an azido and an iodo group, makes it a versatile tool for site-specific conjugation and linker chemistry.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a potent cytotoxic warhead for conjugation to monoclonal antibodies targeting specific cancer cells.
• Bioconjugation Research: Utilized in the development of novel drug-linker systems due to its reactive azide and iodo functional groups for click chemistry and other coupling reactions.
• Oncology Drug Discovery: Acts as a key intermediate in the synthesis of experimental chemotherapeutic agents designed to inhibit microtubule formation.
• Pharmaceutical Intermediate: Employed in the multi-step synthesis of complex, targeted anti-cancer pharmaceuticals.
• Biochemical Probe Development: Used to create labeled compounds for studying cellular uptake, mechanism of action, and intracellular trafficking of vinca alkaloid derivatives.

Basic Information

Item	Detail
Product Name	n-(4-Azido-3-Iodosalicyl)-N'-β-Aminoethylvindesine
CAS No.	102976-56-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-Azido-3-iodosalicyl vindesine derivative; Vindesine azido-iodosalicylamide; Aminoethylvindesine azidoiodosalicyl conjugate; ADC payload intermediate; Vindesine-azido-iodo conjugate; N-(4-Azido-3-iodosalicyl)-N'-(2-aminoethyl)vindesine; 102976-56-7
EINECS	Contact for details

Quality Control

Our n-(4-Azido-3-Iodosalicyl)-N'-β-Aminoethylvindesine is produced under strict quality management protocols to ensure the high purity and consistency required for sensitive research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is strictly light-sensitive and hygroscopic; all handling should be performed in a controlled, dry environment to minimize exposure to moisture and ambient light. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.