Description

trans-2,6-Difluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique difluorinated aromatic structure offers enhanced metabolic stability and lipophilicity, making it invaluable for creating novel compounds with targeted properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise fluorination for product development.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics where fluorine substitution modulates bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro motif can improve environmental stability and efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated organic electronic materials, contributing to the performance of displays and lighting technologies.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl and conjugated systems.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for incorporation into peptide chains or use as a linker in bioconjugation and probe development.
• Academic & R&D: A valuable reagent for medicinal chemistry programs and material science research exploring structure-activity relationships (SAR).

Basic Information

Product Name	trans-2,6-Difluorocinnamic Acid
CAS No.	102082-89-3
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(E)-3-(2,6-Difluorophenyl)acrylic acid; (2E)-3-(2,6-Difluorophenyl)-2-propenoic acid; 2,6-Difluorocinnamic Acid (trans); trans-3-(2,6-Difluorophenyl)acrylic Acid; (E)-3-(2,6-Difluorophenyl)prop-2-enoic acid; 2,6-DFCA
EINECS	Contact for details

Quality Control

Every batch of trans-2,6-Difluorocinnamic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as assay, isomeric purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to minimize moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isomeric Purity (HPLC)	≥ 99.0% (trans isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.