Description

4,5-Difluorophthalic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role in introducing the phthalic acid moiety with specific fluorine substitution, which can significantly alter the electronic and physical properties of target molecules. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to create advanced herbicides and pesticides where fluorine atoms enhance biological activity and environmental stability.
• Polymer & Material Science: Serves as a monomer or modifier for producing high-performance polyimides, polyesters, and other specialty polymers with improved thermal and chemical resistance.
• Liquid Crystal & OLED Materials: Incorporated into the backbone of fluorinated liquid crystals and organic light-emitting diode (OLED) materials to fine-tune electronic properties.
• Organic Synthesis Building Block: Utilized in various coupling reactions and cyclizations to construct complex, fluorinated heterocyclic and aromatic systems.
• Research & Development: A critical reagent in academic and industrial R&D for exploring new fluorination chemistry and structure-activity relationships.

Basic Information

Product Name	4,5-Difluorophthalic Acid
CAS No.	18959-31-4
Molecular Formula	C8H4F2O4
Molecular Weight	202.11 g/mol
Synonyms	1,2-Difluorobenzene-4,5-dicarboxylic Acid; 4,5-Difluorobenzene-1,2-dicarboxylic Acid; 4,5-Difluorophthalic acid; 4,5-Difluoroisophthalic Acid (common misnomer); 18959-31-4; 4,5-Difluoro-1,2-benzenedicarboxylic acid; Difluorophthalic Acid
EINECS	Contact for details

Quality Control

Our 4,5-Difluorophthalic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The container must be kept tightly closed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.