Description

2-[(2-Carboxyphenyl)Amino]-4-(Trifluoromethyl)Benzoic Acid is a high-purity, specialized organic intermediate featuring a unique trifluoromethyl-substituted benzoic acid structure. This compound is valued for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where the trifluoromethyl group imparts desirable metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a sophisticated ligand or precursor in organometallic chemistry for catalytic processes and material science applications.
• Advanced Material Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers requiring specific fluorine-containing motifs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-[(2-Carboxyphenyl)Amino]-4-(Trifluoromethyl)Benzoic Acid
CAS No.	18953-21-4
Molecular Formula	C15H10F3NO4
Molecular Weight	325.24 g/mol
Synonyms	2-[(2-Carboxyanilino)]-4-(trifluoromethyl)benzoic Acid; 2-[(2-Carboxyphenyl)amino]-4-(trifluoromethyl)benzoic Acid; 4-(Trifluoromethyl)-2-[(2-carboxyphenyl)amino]benzoic Acid; 2-[[(2-Carboxyphenyl)amino]-4-(trifluoromethyl)benzoic Acid; 2-Amino-4'-trifluoromethyl-2'-carboxybenzophenone-2-carboxylic Acid (cyclic form); N-(2-Carboxyphenyl)-4-(trifluoromethyl)anthranilic Acid; 18953-21-4; FC-101 Intermediate (proposed)
EINECS	Contact for details

Quality Control

Our 2-[(2-Carboxyphenyl)Amino]-4-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for pharmaceutical and agrochemical synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.