Description

4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylicacid,6-[2-(o-Amino-n-Methylbenzamido)-2-Phenylacetamido]-3,3-Dimethyl-7-Oxo-,Dl-(8Ci) CAS NO 18416-46-1 is a complex, high-purity pharmaceutical intermediate belonging to the penicillin and cephalosporin structural family. This compound is critical for the research and development of novel β-lactam antibiotics, offering a key building block for advanced synthetic pathways. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel β-lactam antibiotic candidates and related pharmacologically active molecules.
• Research & Development: Used in academic and industrial research for studying structure-activity relationships (SAR) and developing new antimicrobial agents.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex molecular architectures in custom synthesis projects.
• API Development: Employed in the process development and scale-up stages for new Active Pharmaceutical Ingredients targeting bacterial infections.
• Biochemical Research: Potential use as a tool compound in enzymatic studies related to bacterial cell wall synthesis and inhibition.

Basic Information

Item	Detail
Product Name	4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylicacid,6-[2-(o-Amino-n-Methylbenzamido)-2-Phenylacetamido]-3,3-Dimethyl-7-Oxo-,Dl-(8Ci)
CAS No.	18416-46-1
Molecular Formula	C24H26N4O5S
Molecular Weight	482.55 g/mol
Synonyms	6-[2-(2-Amino-N-methylbenzamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; DL-6-(2-(2-Amino-N-methylbenzamido)-2-phenylacetamido)penicillanic acid; Ampicillin related compound; A penicillin derivative intermediate; (2S,5R,6R)-6-[(2R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid analog; 6-APA derivative; β-lactam intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, IR). We provide full traceability and Certificates of Analysis (COA) are supplied with each shipment, detailing all specified parameters. Quality standards can be aligned with cGMP requirements for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.