Description

4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylicacid,6-[2-(6-Amino-n-Methyl-m-Toluamido)-2-Phenylacetamido]-3,3-Dimethyl-7-Oxo-,Dl-(8Ci) CAS NO 18416-39-2 is a complex heterocyclic compound belonging to the penicillin core family, serving as a key advanced intermediate in pharmaceutical synthesis. Its value lies in enabling the production of high-purity, specialized β-lactam antibiotics and other active pharmaceutical ingredients (APIs). This product is essential for research organizations, fine chemical manufacturers, and pharmaceutical companies engaged in the development and commercial-scale synthesis of next-generation antimicrobial agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel penicillin and cephalosporin derivatives.
• API Synthesis: Used in the production of active pharmaceutical ingredients (APIs) for antibacterial medications.
• Research & Development: Enables medicinal chemistry research for developing new antibiotics with improved efficacy and resistance profiles.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of complex, high-value specialty chemicals.
• Process Chemistry: Employed in process development and optimization for scalable, GMP-compliant manufacturing routes.

Basic Information

Item	Details
Product Name	4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylicacid,6-[2-(6-Amino-n-Methyl-m-Toluamido)-2-Phenylacetamido]-3,3-Dimethyl-7-Oxo-,Dl-(8Ci)
CAS No.	18416-39-2
Molecular Formula	C24H26N4O5S
Molecular Weight	482.55 g/mol
Synonyms	6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; DL-6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Ampicillin intermediate; 6-APA derivative; 6-[(Aminophenylacetyl)amino]penicillanic acid; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-; (2S,5R,6R)-6-[(2-Amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (stereoisomer reference)
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, supporting development under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.