Description

4-Fluorobenzoyl Isocyanate is a highly reactive and versatile fluorinated aromatic building block essential for advanced organic synthesis. Its core value lies in introducing both the 4-fluorobenzoyl and reactive isocyanate functional groups into target molecules, enabling the creation of novel compounds with tailored properties. This intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing fluorinated benzamide or urea moieties.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and stability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing specialty polymers, polyurethanes, and coatings with specific thermal or chemical resistance.
• Ligand & Catalyst Development: Employed in the synthesis of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Peptide & Protein Modification: Useful for selective modification of amino groups in peptides and biomolecules under controlled conditions.
• Chemical Research & Development: A fundamental reagent for exploring new reaction pathways and creating fluorinated compound libraries for screening.

Basic Information

Product Name	4-Fluorobenzoyl Isocyanate
CAS No.	18354-35-3
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	p-Fluorobenzoyl Isocyanate; 4-Fluorobenzoic Acid Isocyanate; 4-Fluorobenzoyl Isocyanate; Isocyanic Acid 4-Fluorobenzoyl Ester; 1-Isocyanato-4-fluorobenzene-1-carboxaldehyde (tautomer); 4-Fluorobenzoylazane (alternative); 4-Fluorobenzoylisocyanat (German); (4-Fluorobenzoyl)isocyanate
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzoyl Isocyanate is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, this material must be stored under a dry, inert atmosphere (e.g., nitrogen or argon) in a cool, well-ventilated area. Recommended storage temperature is 2-8°C. Keep away from strong acids, bases, alcohols, amines, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.