Description

2,6-Difluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the benzoyl chloride core, which significantly influences the electronic properties and metabolic stability of final target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules like active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifier in the synthesis of specialty polymers, including high-performance engineering plastics and coatings.
• Dye & Pigment Manufacturing: Intermediate for creating novel fluorine-containing dyes and pigments with improved color fastness and stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl structures.
• Peptide & Protein Research: Used for the selective acylation of amino groups in peptide synthesis and bioconjugation strategies.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new fluorinated compounds and reaction methodologies.

Basic Information

Product Name	2,6-Difluorobenzoyl Chloride
CAS No.	18063-02-0
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2,6-Difluorobenzoyl chloride; Benzoyl chloride, 2,6-difluoro-; 2,6-Difluorobenzoic acid chloride; α,α,2,6-Tetrafluorotoluene (obsolete); 2,6-Difluorobenzoic acid chloride; 2,6-Difluorobenzoylchlorid; 2,6-Difluorobenzoyl Chloride (DFBC)
EINECS	Contact for details

Quality Control

Our 2,6-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and a strong acid/organic solvent. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines. Use under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to minimize degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acid Value	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.