Description

2-Bromo-3,4,5,6-Tetrafluorobenzoic Acid is a highly functionalized aromatic building block characterized by its halogen and fluorine substituents. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for constructing novel active ingredients and materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the bromo and tetrafluoro substituents impart specific biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Polymer Modification: Employed to introduce fluorinated benzoic acid groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create diverse biaryl structures.
• Ligand & Catalyst Development: Utilized in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis and other specialized catalytic processes.

Basic Information

Product Name	2-Bromo-3,4,5,6-Tetrafluorobenzoic Acid
CAS No.	16583-04-3
Molecular Formula	C7HBrF4O2
Molecular Weight	264.98 g/mol
Synonyms	Benzoic acid, 2-bromo-3,4,5,6-tetrafluoro-; 3,4,5,6-Tetrafluoro-2-bromobenzoic Acid; 2-Bromo-3,4,5,6-tetrafluorobenzoic acid; 2-Bromotetrafluorobenzoic Acid; Tetrafluorobromobenzoic Acid; BTFBA; NSC 403107
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4,5,6-Tetrafluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its strong acid/organic solvent nature, keep away from incompatible materials such as strong bases and oxidizing agents. The container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.