Description

2,3,4,5-Tetrafluorobenzamide is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique tetrafluorinated benzamide structure makes it a critical intermediate for developing active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and material science industries, where precise fluorination patterns are required to modulate biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics where fluorination enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms contribute to improved lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to desired dielectric and optical properties.
• Polymer Modification: Employed to introduce fluorine into polymer backbones or side chains, enhancing chemical resistance, thermal stability, and surface properties of high-performance plastics.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and amide bond transformations to create complex, fluorinated molecular architectures for research.
• Chemical Research & Development: A valuable reagent for exploring structure-activity relationships (SAR) in medicinal chemistry and material science programs.

Basic Information

Product Name	2,3,4,5-Tetrafluorobenzamide
CAS No.	16582-94-8
Molecular Formula	C7H3F4NO
Molecular Weight	193.10 g/mol
Synonyms	Benzamide, 2,3,4,5-tetrafluoro-; 2,3,4,5-Tetrafluorobenzoic acid amide; Tetrafluorobenzamide; 2,3,4,5-Tetrafluorobenzene-1-carboxamide; Perfluorobenzamide (ambiguous, but sometimes used); NSC 406906; AI3-00632; 1-Carbamoyl-2,3,4,5-tetrafluorobenzene
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrafluorobenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.