Description

4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 6-(2-Amino-2-Phenylacetamido)-3,3-Dimethyl-7-Oxo-, Monosodium Salt (8Ci) is a high-purity pharmaceutical intermediate, specifically the monosodium salt of a penicillin derivative. This compound is critical for ensuring the quality and efficacy of downstream active pharmaceutical ingredients (APIs) in antibiotic manufacturing. It is primarily required by pharmaceutical companies and research institutions engaged in the development and production of β-lactam antibiotics.

Application

• Key Intermediate in the synthesis of semi-synthetic penicillin and penicillin-based APIs.
• Pharmaceutical Research for developing new antibiotic compounds and studying β-lactam structures.
• Quality Control Standard used as a reference standard in analytical laboratories for HPLC and spectroscopic methods.
• Process Chemistry for scale-up and optimization of antibiotic production pathways.
• Biochemical Studies investigating the mechanism of action and resistance of β-lactam antibiotics.

Basic Information

Product Name	4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 6-(2-Amino-2-Phenylacetamido)-3,3-Dimethyl-7-Oxo-, Monosodium Salt (8Ci)
CAS No.	15497-42-4
Molecular Formula	C16H19N3NaO4S
Molecular Weight	372.40 g/mol
Synonyms	6-APA Sodium Salt (derivative); Sodium 6-Aminopenicillanate (related form); Ampicillin Intermediate; D-(-)-α-Aminobenzylpenicillin Sodium Salt Precursor; Monosodium (2S,5R,6R)-6-[(2R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Penicillin G Amine Sodium Salt; 6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our 4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid, 6-(2-Amino-2-Phenylacetamido)-3,3-Dimethyl-7-Oxo-, Monosodium Salt (8Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.